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Exeter wing Jack Nowell and Northampton centre Luther Burrell will make their England debuts in Saturday's Six Nations opener against France. There are four changes in all from the side that lost 30-22 to New Zealand at Twickenham in November. Gloucester winger Jonny May will win his second cap at Stade de France, while Harlequins' Danny Care has been recalled at scrum-half. Quins' Joe Marler retains his place at loose-head prop ahead of Mako Vunipola.